Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.33 |
| ▸ | CCKAR | P32238 | 2/20 | 0.31 |
| ▸ | CCKBR | P32239 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464013 | 1.00 | BTK (0.38) | BTKDEGS1CCKARCCKBRNPC1 | |
| SCHEMBL2464418 | 0.85 | PPARG (0.36) | BTKDEGS1NPC1MAPTRAB9A | |
| SCHEMBL2462892 | 0.85 | PPARG (0.36) | BTKDEGS1NPC1MAPTRAB9A | |
| SCHEMBL9985142 | 0.77 | BTK (0.48) | BTKDEGS1 | |
| SCHEMBL2491394 | 0.77 | BTK (0.48) | BTKDEGS1 | |
| SCHEMBL9985729 | 0.77 | BTK (0.48) | BTKDEGS1 | |
| SCHEMBL2464076 | 0.76 | BTK (0.59) | BTKDEGS1MEN1KMT2AF10 | |
| SCHEMBL2464078 | 0.76 | BTK (0.59) | BTKDEGS1MEN1KMT2AF10 | |
| SCHEMBL2466168 | 0.76 | BTK (0.59) | BTKDEGS1MEN1KMT2AF10 | |
| SCHEMBL2461785 | 0.73 | PPARG (0.38) | BTKDEGS1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-A1 | Pyridazinones and their use as btk inhibitors | CGI Pharmaceuticals, Inc. (US) | 2011-09-21 | — | — | EP | claimed |
| WO-2010056875-A1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | claimed |