SCHEMBL246286

SCHEMBL246286

O=[N+]([O-])c1cccc(COCCCCBr)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.50
MAOB P27338 2/20 0.49
MAOA P21397 1/20 0.49
RAB9A P51151 1/20 0.45
F2 P00734 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
LMNA P02545 2/20 0.44
ALDH1A1 P00352 2/20 0.43
HTR1A P08908 1/20 0.43
ADRA1D P25100 1/20 0.43
ADRA1A P35348 1/20 0.43
ADRA1B P35368 1/20 0.43
POLB P06746 1/20 0.43
TP53 P04637 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL928220 0.96 TSHR (0.47) TSHRMAOBMAOARAB9AF2
SCHEMBL926155 0.96 TSHR (0.47) TSHRMAOBMAOARAB9AF2
SCHEMBL925116 0.96 TSHR (0.47) TSHRMAOBMAOARAB9AF2
SCHEMBL927464 0.96 TSHR (0.47) TSHRMAOBMAOARAB9AF2
SCHEMBL14662625 0.96 TSHR (0.51) TSHRMAOBMAOARAB9AF2
SCHEMBL5093977 0.90 MAOB (0.45) TSHRMAOBMAOARAB9AF2
SCHEMBL9763338 0.86 TSHR (0.48) TSHRMAOBMAOACYP1A2CYP2D6
SCHEMBL926393 0.84 TSHR (0.51) TSHRMAOBMAOARAB9AF2
SCHEMBL6255009 0.84 TSHR (0.51) TSHRMAOBMAOARAB9AF2
SCHEMBL6251727 0.84 TSHR (0.59) TSHRMAOBMAOAF2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012003418-A2 FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D2 RECEPTORS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2012-01-05 WO disclosed