Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP5 | Q01469 | 3/20 | 0.47 |
| ▸ | FABP7 | O15540 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30686129 | 1.00 | FABP5 (0.47) | FABP5FABP7KMT2AEPHX2CASP3 | |
| SCHEMBL24633596 | 1.00 | FABP5 (0.47) | FABP5FABP7KMT2AEPHX2CASP3 | |
| SCHEMBL30686140 | 1.00 | FABP5 (0.47) | FABP5FABP7KMT2AEPHX2CASP3 | |
| SCHEMBL21287095 | 0.86 | FABP5 (0.44) | FABP5FABP7KMT2AEPHX2CASP3 | |
| SCHEMBL30062797 | 0.84 | FABP5 (0.44) | FABP5FABP7KMT2AEPHX2CASP3 | |
| SCHEMBL1827945 | 0.84 | FABP5 (0.52) | FABP5FABP7KMT2AEPHX2CASP3 | |
| SCHEMBL8430197 | 0.84 | FABP5 (0.46) | FABP5FABP7KMT2AEPHX2CASP3 | |
| SCHEMBL7202660 | 0.84 | FABP5 (0.52) | FABP5FABP7KMT2AEPHX2CASP3 | |
| SCHEMBL7202664 | 0.84 | FABP5 (0.52) | FABP5FABP7KMT2AEPHX2CASP3 | |
| SCHEMBL9131023 | 0.83 | FABP5 (0.44) | FABP5FABP7KMT2AEPHX2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024101402-A1 | PHARMACEUTICAL COMPOSITION CONTAINING CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT AGAINST HRAS AND NRAS | 中外製薬株式会社 | 2024-05-16 | — | — | WO | disclosed |
| WO-2023214576-A1 | CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS | 中外製薬株式会社 | 2023-11-09 | — | — | WO | disclosed |
| WO-2022234853-A1 | CYCLIC COMPOUND HAVING INHIBITORY EFFECT SELECTIVE FOR KRAS BUT NOT FOR HRAS AND NRAS | 中外製薬株式会社 | 2022-11-10 | — | — | WO | disclosed |