Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 6/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.52 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.52 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30876696 | 0.96 | HTT (0.66) | HTTSMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL24634613 | 0.96 | HTT (0.66) | HTTSMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL24634702 | 0.91 | HTT (0.61) | HTTSMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL30876579 | 0.91 | HTT (0.61) | HTTSMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL27196458 | 0.90 | HTT (0.58) | HTTSMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL30876621 | 0.90 | HTT (0.58) | HTTSMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL24634716 | 0.88 | HTT (0.62) | HTTSMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL30876666 | 0.88 | HTT (0.62) | HTTSMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL29856037 | 0.84 | HTT (0.53) | HTTSMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL27196497 | 0.84 | HTT (0.53) | HTTSMN1; SMN2KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169834-A2 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-08-11 | — | — | WO | disclosed |