Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.76 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.69 |
| ▸ | INSR | P06213 | 1/20 | 0.69 |
| ▸ | LYN | P07948 | 1/20 | 0.69 |
| ▸ | RET | P07949 | 1/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.69 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.69 |
| ▸ | FLT4 | P35916 | 1/20 | 0.69 |
| ▸ | FLT3 | P36888 | 1/20 | 0.69 |
| ▸ | FRK | P42685 | 1/20 | 0.69 |
| ▸ | STK3 | Q13188 | 1/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.69 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.69 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.69 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.69 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.69 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.69 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2463378 | 0.91 | IGF1R (0.81) | IGF1RTNK2 | |
| SCHEMBL2457735 | 0.91 | IGF1R (0.80) | IGF1RROCK2PRKD3INSRLYN | |
| SCHEMBL2463556 | 0.91 | IGF1R (0.79) | IGF1RTNK2 | |
| SCHEMBL2460665 | 0.90 | IGF1R (0.78) | IGF1RTNK2 | |
| SCHEMBL2466131 | 0.90 | IGF1R (0.78) | IGF1RTNK2 | |
| SCHEMBL2464417 | 0.90 | IGF1R (0.83) | IGF1RTNK2 | |
| SCHEMBL2464840 | 0.89 | IGF1R (0.77) | IGF1RTNK2 | |
| SCHEMBL2460158 | 0.89 | IGF1R (0.77) | IGF1RTNK2 | |
| SCHEMBL2460384 | 0.89 | IGF1R (0.82) | IGF1RTNK2 | |
| Bicarbonate SCHEMBL2464578 | 0.89 | IGF1R (0.93) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675860-B1 | IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS | OSI PHARM INC (US) | 2011-09-21 | — | — | EP | claimed |