Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10665254 | 0.85 | POLB (0.45) | POLBMAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL19639571 | 0.84 | SMN1; SMN2 (0.68) | POLBMAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL18251624 | 0.84 | SMN1; SMN2 (0.68) | POLBMAPTKDM4ESMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL18245740 | 0.83 | SMN1; SMN2 (0.67) | POLBMAPTKDM4ESMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL18245742 | 0.83 | SMN1; SMN2 (0.67) | POLBMAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL18251634 | 0.80 | SMN1; SMN2 (0.49) | POLBMAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL10665245 | 0.80 | MAPT (0.46) | POLBMAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL10665249 | 0.80 | MAPT (0.46) | POLBMAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL18251630 | 0.79 | SMN1; SMN2 (0.51) | POLBMAPTKDM4ESMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL18245693 | 0.79 | SMN1; SMN2 (0.48) | POLBMAPTKDM4ESMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220267258-A1 | ROBENIDINE ANALOGS AS POTENT ANTIMALARIALS AGAINST DRUG-RESISTANT PLASMODIUM FALCIPARUM | UNIV OREGON HEALTH & SCIENCE (US) | 2022-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220267258-A1 | ROBENIDINE ANALOGS AS POTENT ANTIMALARIALS AGAINST DRUG-RESISTANT PLASMODIUM FALCIPARUM | CYP3A43, CYP2C9, CYP3A4 | POLB 1310/4885MAPT 277/4885KDM4E 4199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.