Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | TIPARP | Q7Z3E1 | 11/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24640176 | 1.00 | SOS1 (0.38) | SOS1TIPARPPARP2BTKPDE9A | |
| SCHEMBL24640222 | 1.00 | SOS1 (0.38) | SOS1TIPARPPARP2BTKPDE9A | |
| SCHEMBL24640189 | 0.96 | SOS1 (0.37) | SOS1TIPARPPARP2HRH3AXL | |
| SCHEMBL24640224 | 0.96 | SOS1 (0.37) | SOS1TIPARPPARP2HRH3AXL | |
| SCHEMBL24640196 | 0.96 | SOS1 (0.37) | SOS1TIPARPPARP2HRH3AXL | |
| SCHEMBL24640612 | 0.90 | AXL (0.36) | SOS1TIPARPPARP2HRH3AXL | |
| SCHEMBL24639358 | 0.86 | SOS1 (0.41) | SOS1TIPARPPARP2PIK3CD | |
| SCHEMBL24639353 | 0.86 | SOS1 (0.41) | SOS1TIPARPPARP2PIK3CD | |
| SCHEMBL24639388 | 0.85 | TIPARP (0.45) | SOS1TIPARPPARP2HRH3CYP3A4 | |
| SCHEMBL24639386 | 0.85 | TIPARP (0.45) | SOS1TIPARPPARP2HRH3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |