Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5C | P41229 | 3/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KDM6B | O15054 | 2/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | TIPARP | Q7Z3E1 | 8/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24640471 | 1.00 | KDM5C (0.36) | KDM5CKDM4CKDM2ARAB9AKDM4E | |
| SCHEMBL24640469 | 1.00 | KDM5C (0.36) | KDM5CKDM4CKDM2ARAB9AKDM4E | |
| SCHEMBL31245431 | 0.91 | TIPARP (0.38) | TIPARPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL24640462 | 0.88 | MDM2 (0.42) | KDM5CKDM4CKDM2ARAB9AKDM4E | |
| SCHEMBL24640453 | 0.88 | MDM2 (0.42) | KDM5CKDM4CKDM2ARAB9AKDM4E | |
| SCHEMBL24640467 | 0.88 | MDM2 (0.42) | KDM5CKDM4CKDM2ARAB9AKDM4E | |
| SCHEMBL24640468 | 0.86 | TIPARP (0.44) | TIPARPCYP2C9CYP2C19MDM2PARP2 | |
| SCHEMBL24640451 | 0.86 | TIPARP (0.44) | TIPARPCYP2C9CYP2C19MDM2PARP2 | |
| SCHEMBL24640452 | 0.86 | TIPARP (0.44) | TIPARPCYP2C9CYP2C19MDM2PARP2 | |
| SCHEMBL24639518 | 0.82 | JAK3 (0.37) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |