SCHEMBL24640683

SCHEMBL24640683

CC(C)N1CCN2c3ncc(C(F)(F)F)cc3N(C3CCC3)C(=O)C2C1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TIPARP Q7Z3E1 6/20 0.37
HRH3 Q9Y5N1 3/20 0.36
ACACB O00763 2/20 0.35
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
HTT P42858 1/20 0.34
MDM2 Q00987 2/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
NR1H2 P55055 1/20 0.34
NR1H3 Q13133 1/20 0.34
CXCR3 P49682 1/20 0.33
CNR1 P21554 1/20 0.33
CNR2 P34972 1/20 0.33
GAA P10253 1/20 0.32
ATM Q13315 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24640001 1.00 TIPARP (0.37) TIPARPHRH3ACACBALDH1A1LMNA
SCHEMBL24639983 0.96 TIPARP (0.38) TIPARPHRH3ACACBALDH1A1LMNA
SCHEMBL24639984 0.87 TIPARP (0.40) TIPARPALDH1A1LMNAHTTMDM2
SCHEMBL24640747 0.85 TIPARP (0.40) TIPARPHRH3ACACBALDH1A1LMNA
SCHEMBL24640010 0.84 TIPARP (0.48) TIPARPHRH3ACACBALDH1A1LMNA
SCHEMBL24639999 0.84 TIPARP (0.48) TIPARPHRH3ACACBALDH1A1LMNA
SCHEMBL24639351 0.82 TIPARP (0.41) TIPARPHRH3ACACBALDH1A1LMNA
SCHEMBL24640736 0.82 TIPARP (0.41) TIPARPHRH3ACACBALDH1A1LMNA
SCHEMBL24639327 0.82 TIPARP (0.41) TIPARPHRH3ACACBALDH1A1LMNA
SCHEMBL24639329 0.81 TIPARP (0.51) TIPARPHRH3ACACBALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022170974-A1 TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS JACOBIO PHARMACEUTICALS CO., LTD. (CN) 2022-08-18 WO disclosed