Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2466403 | 0.93 | ATR (0.60) | ATR | |
| SCHEMBL2467387 | 0.89 | ATR (0.52) | ATR | |
| SCHEMBL2465838 | 0.86 | ATR (0.53) | ATR | |
| SCHEMBL2464833 | 0.86 | ATR (0.53) | ATR | |
| SCHEMBL2469766 | 0.85 | ATR (0.53) | ATR | |
| SCHEMBL2462641 | 0.85 | ATR (0.53) | ATR | |
| SCHEMBL2469310 | 0.82 | ATR (0.50) | ATR | |
| SCHEMBL2465966 | 0.80 | ATR (0.55) | ATR | |
| SCHEMBL617534 | 0.75 | ATR (0.66) | ATR | |
| SCHEMBL614408 | 0.74 | ATR (0.66) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370424-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010054398-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-14 | — | — | WO | disclosed |