Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL6910520 | 1.00 | TSHR (1.00) | TSHRALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| Alcohol SCHEMBL9461084 | 1.00 | TSHR (1.00) | TSHRALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| Alcohol SCHEMBL17770701 | 1.00 | — | — | |
| Alcohol SCHEMBL463 | 1.00 | — | — | |
| Alcohol SCHEMBL54946 | 1.00 | — | — | |
| Alcohol SCHEMBL2023653 | 1.00 | — | — | |
| Alcohol SCHEMBL27342073 | 1.00 | TSHR (1.00) | TSHRALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| Alcohol SCHEMBL25351029 | 0.93 | — | — | |
| Alcohol SCHEMBL22443657 | 0.93 | — | — | |
| Alcohol SCHEMBL21816702 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364147-A2 | COMPOSITIONS COMPRISING 1-ARYLPYRAZOLE ALONE OR IN COMBINATION WITH FORMAMIDINE FOR THE TREATMENT OF PARASITIC INFECTION | Merial Limited (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010059529-A2 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND/OR A FORMAMIDINE, METHODS AND USES THEREOF | MERIAL LIMITED (US) | 2010-05-27 | — | — | WO | disclosed |
| US-4900465-A | Process for preparing magnetic carbon black | TOKAI CARBON CO., LTD. (JP) | 1990-02-13 | — | — | US | disclosed |
| US-4769358-A | CESIUM COMPOUND | NIPPON SHOKUBAI KAGAKU KOGYO CO., LTD. (JP) | 1988-09-06 | — | — | US | disclosed |