Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 15/20 | 0.57 |
| ▸ | RIPK1 | Q13546 | 9/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.57 |
| ▸ | EIF2AK2 | P19525 | 4/20 | 0.57 |
| ▸ | EIF2AK1 | Q9BQI3 | 4/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.57 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.57 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | YES1 | P07947 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NEK4 | P51957 | 1/20 | 0.47 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.47 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30120821 | 1.00 | EIF2AK3 (0.57) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL24650644 | 0.94 | EIF2AK3 (0.56) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL30120856 | 0.94 | EIF2AK3 (0.56) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL30120815 | 0.94 | EIF2AK3 (0.54) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL24651171 | 0.94 | EIF2AK3 (0.54) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL24651063 | 0.94 | EIF2AK3 (0.56) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL30120844 | 0.94 | EIF2AK3 (0.56) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL24651168 | 0.92 | EIF2AK3 (0.54) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL30120843 | 0.92 | EIF2AK3 (0.54) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL30120917 | 0.89 | EIF2AK3 (0.52) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212326-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-10-06 | — | — | WO | disclosed |