Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 13/20 | 0.80 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.80 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.80 |
| ▸ | EIF2AK1 | Q9BQI3 | 3/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.80 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.80 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | SIK1 | P57059 | 1/20 | 0.45 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | DSTYK | Q6XUX3 | 1/20 | 0.45 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.45 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24650640 | 0.90 | EIF2AK3 (0.80) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL870782 | 0.89 | EIF2AK3 (1.00) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL869311 | 0.81 | EIF2AK3 (0.84) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL29911677 | 0.80 | EIF2AK3 (0.81) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL23060140 | 0.80 | EIF2AK3 (0.81) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL24651063 | 0.80 | EIF2AK3 (0.56) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL30120844 | 0.80 | EIF2AK3 (0.56) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL24651195 | 0.80 | SRC (0.53) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL868814 | 0.79 | EIF2AK3 (1.00) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL29911579 | 0.79 | EIF2AK3 (1.00) | EIF2AK3RIPK1CYP3A4EIF2AK2EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240382488-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. | 2024-11-21 | — | — | US | disclosed |
| WO-2022212326-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-10-06 | — | — | WO | disclosed |
| WO-2022212326-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240382488-A1 | NEK7 INHIBITORS | NEK7, NEK11, NEK2 | EIF2AK3 2387/4885RIPK1 537/4885CYP3A4 2703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.