Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 17/20 | 0.61 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2466400 | 0.95 | BACE1 (0.67) | BACE1KCNH2BACE2 | |
| SCHEMBL2464071 | 0.90 | BACE1 (0.48) | BACE1KCNH2BACE2 | |
| SCHEMBL2461223 | 0.87 | BACE1 (0.58) | BACE1KCNH2BACE2 | |
| SCHEMBL2466808 | 0.86 | BACE1 (0.66) | BACE1KCNH2BACE2 | |
| SCHEMBL24363070 | 0.85 | BACE1 (0.81) | BACE1KCNH2BACE2 | |
| SCHEMBL25916289 | 0.85 | BACE1 (0.81) | BACE1KCNH2BACE2 | |
| SCHEMBL2464309 | 0.82 | BACE1 (0.83) | BACE1KCNH2BACE2 | |
| SCHEMBL2464787 | 0.82 | BACE1 (0.66) | BACE1KCNH2BACE2 | |
| SCHEMBL2463623 | 0.81 | BACE1 (0.51) | BACE1KCNH2BACE2 | |
| SCHEMBL27860634 | 0.80 | BACE1 (0.49) | BACE1KCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367814-A1 | NEW COMPOUNDS 578 | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |