SCHEMBL2465794

SCHEMBL2465794

NC1(C=O)CCc2ccccc21

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 3/20 0.46
MAOB P27338 1/20 0.46
TSHR P16473 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
HDAC9 Q9UKV0 1/20 0.38
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
HTR2A P28223 2/20 0.37
ALDH1A1 P00352 1/20 0.36
TP53 P04637 1/20 0.36
HCAR2 Q8TDS4 1/20 0.36
HTR2C P28335 1/20 0.36
HTR2B P41595 1/20 0.36
SIGMAR1 Q99720 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7445452 1.00 KDM1A (0.46) KDM1AMAOBTSHRTDP1HDAC9
SCHEMBL6495897 0.89 KDM1A (0.51) KDM1AMAOBTSHRMEN1KMT2A
Hydrochloric Acid SCHEMBL4427642 0.87 KDM1A (0.50) KDM1AMAOBMEN1KMT2ASIGMAR1
SCHEMBL6267106 0.77 KDM1A (0.53) KDM1AMAOBTSHRTDP1HDAC9
SCHEMBL29784907 0.77 KDM1A (0.53) KDM1AMAOBTSHRTDP1HDAC9
Hydrochloric Acid SCHEMBL29189207 0.75 KDM1A (0.52) KDM1AMAOBTSHRTDP1HDAC9
SCHEMBL23987371 0.75 KDM1A (0.41) KDM1ATDP1MEN1KMT2AALDH1A1
SCHEMBL6881229 0.74 KDM1A (0.43) KDM1AMAOBTSHRTDP1HDAC9
SCHEMBL12305110 0.73 MEN1 (0.44) KDM1AMAOBTSHRTDP1HDAC9
Formamide SCHEMBL28879585 0.72 KDM1A (0.45) KDM1AMAOBTSHRTDP1HDAC9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4782252-B2 2011-09-28 JP claimed
US-6528685-B2 Such as (R)-N-(2-acetamido)-1-aminoindan for treatment of Parkinson's disease, dementia, epilepsy, convulsions, or seizures TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 2003-03-04 US claimed
EP-0738149-A4 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMA (IL) 1999-10-27 EP claimed
EP-0738149-A1 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 1996-10-23 EP claimed
WO-1995018617-A1 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 1995-07-13 WO claimed
EP-0738149-A4 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMA (IL) 1999-10-27 EP disclosed
EP-0738149-A1 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 1996-10-23 EP disclosed
WO-1996021640-A1 OPTICALLY ACTIVE AMINOINDANE DERIVATIVES AND PREPARATION THEREOF TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 1996-07-18 WO disclosed
WO-1995018617-A1 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 1995-07-13 WO disclosed