Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.61 |
| ▸ | JAK1 | P23458 | 9/20 | 0.61 |
| ▸ | TYK2 | P29597 | 9/20 | 0.61 |
| ▸ | JAK3 | P52333 | 9/20 | 0.61 |
| ▸ | BTK | Q06187 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL145751 | 0.91 | JAK2 (0.72) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL142552 | 0.89 | JAK2 (0.61) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL2466858 | 0.89 | JAK2 (0.61) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL139673 | 0.85 | JAK2 (0.57) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL139639 | 0.84 | JAK2 (0.57) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL2471637 | 0.84 | JAK2 (0.54) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL2465637 | 0.81 | JAK2 (0.50) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL142478 | 0.81 | JAK2 (0.53) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL142310 | 0.81 | JAK2 (0.70) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL140904 | 0.79 | JAK2 (0.86) | JAK2JAK1TYK2JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370407-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010080474-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |