Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2534943 | 0.80 | POLB (0.48) | POLBMAPTTP53KDM4EMEN1 | |
| SCHEMBL462636 | 0.76 | HTR1D (0.59) | POLBMAPTTP53KDM4EMEN1 | |
| SCHEMBL438686 | 0.76 | TSHR (0.46) | POLBEPHX2MAPTTP53KDM4E | |
| SCHEMBL440930 | 0.76 | TSHR (0.46) | POLBEPHX2MAPTTP53KDM4E | |
| Hydrochloric Acid SCHEMBL442488 | 0.76 | HTR1D (0.58) | POLBMAPTTP53KDM4EMEN1 | |
| SCHEMBL442492 | 0.76 | POLB (0.41) | POLBEPHX2MAPTTP53KDM4E | |
| SCHEMBL462757 | 0.76 | POLB (0.43) | POLBMAPTTP53KDM4EMEN1 | |
| SCHEMBL406769 | 0.75 | MAPT (0.49) | POLBMAPTTP53KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL438242 | 0.75 | TSHR (0.45) | POLBEPHX2MAPTTP53KDM4E | |
| SCHEMBL12224913 | 0.75 | POLB (0.43) | POLBMAPTTP53KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011112731-A2 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2011-09-15 | — | — | WO | disclosed |