Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.64 |
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24667319 | 1.00 | ABL1 (0.64) | ABL1MAP4K1LRRK2LYNSRC | |
| SCHEMBL24667324 | 0.93 | ABL1 (0.56) | ABL1MAP4K1LRRK2 | |
| SCHEMBL24666426 | 0.93 | ABL1 (0.56) | ABL1MAP4K1LRRK2 | |
| SCHEMBL24666966 | 0.93 | ABL1 (0.56) | ABL1MAP4K1LRRK2 | |
| SCHEMBL24666972 | 0.91 | ABL1 (0.54) | ABL1MAP4K1LRRK2 | |
| SCHEMBL24664995 | 0.91 | ABL1 (0.61) | ABL1MAP4K1LRRK2 | |
| SCHEMBL24664996 | 0.91 | ABL1 (0.61) | ABL1MAP4K1LRRK2 | |
| SCHEMBL24665005 | 0.91 | ABL1 (0.61) | ABL1MAP4K1LRRK2 | |
| SCHEMBL24664999 | 0.91 | ABL1 (0.61) | ABL1MAP4K1LRRK2 | |
| SCHEMBL24666436 | 0.90 | ABL1 (0.60) | ABL1MAP4K1LYNSRCBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022236319-A1 | NAPHTHYRIDONE COMPOUNDS FOR INHIBITION OF RAF KINASES AND/OR BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |