Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.38 |
| ▸ | KRAS | P01116 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29977440 | 0.92 | SRC (0.39) | SRCFGFR1FGFR4KRASRAF1 | |
| SCHEMBL24666788 | 0.92 | SRC (0.39) | SRCFGFR1FGFR4KRASRAF1 | |
| SCHEMBL24666550 | 0.87 | GSK3B (0.40) | SRCFGFR1FGFR4KRASRAF1 | |
| SCHEMBL24666839 | 0.86 | ABL1 (0.47) | ABL1 | |
| SCHEMBL24666749 | 0.86 | ABL1 (0.47) | ABL1 | |
| SCHEMBL24666832 | 0.86 | ABL1 (0.47) | ABL1 | |
| SCHEMBL24667341 | 0.85 | ABL1 (0.43) | SRCFGFR1KRASRAF1BRAF | |
| SCHEMBL24665076 | 0.85 | SRC (0.41) | SRCFGFR1FGFR4KRASRAF1 | |
| SCHEMBL24665103 | 0.84 | ABL1 (0.49) | SRCFGFR1FGFR4KRASRAF1 | |
| SCHEMBL24665104 | 0.84 | ABL1 (0.49) | SRCFGFR1FGFR4KRASRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022236319-A1 | NAPHTHYRIDONE COMPOUNDS FOR INHIBITION OF RAF KINASES AND/OR BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |
| WO-2022236319-A1 | NAPHTHYRIDONE COMPOUNDS FOR INHIBITION OF RAF KINASES AND/OR BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |