Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 19/20 | 0.56 |
| ▸ | CDK2 | P24941 | 19/20 | 0.56 |
| ▸ | CCND1 | P24385 | 17/20 | 0.56 |
| ▸ | CDK6 | Q00534 | 17/20 | 0.56 |
| ▸ | CDK4 | P11802 | 3/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 2/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.51 |
| ▸ | RB1 | P06400 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CCND3 | P30281 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24668767 | 0.97 | CCNE1 (0.55) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24668617 | 0.87 | CCNE1 (0.53) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24667996 | 0.85 | CCNE1 (0.56) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669203 | 0.85 | CCNE1 (0.63) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24668002 | 0.84 | CCNE1 (0.51) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669757 | 0.83 | CCNE1 (0.51) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24668808 | 0.83 | CCNE1 (0.56) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24667769 | 0.81 | CCNE1 (0.56) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669680 | 0.81 | CCNE1 (0.59) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669210 | 0.80 | CCNE1 (0.70) | CCNE1CDK2CCND1CDK6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |