Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 15/20 | 0.39 |
| ▸ | CDK2 | P24941 | 15/20 | 0.39 |
| ▸ | CCND1 | P24385 | 13/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 13/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | RB1 | P06400 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24669563 | 0.93 | CCNE1 (0.39) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL24669732 | 0.87 | CCNE1 (0.39) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL24669139 | 0.79 | CCNE1 (0.51) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL24668782 | 0.77 | CCNE1 (0.49) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL24668676 | 0.77 | CCNE1 (0.55) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL24670451 | 0.77 | CCNE1 (0.49) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL24669157 | 0.75 | CCNE1 (0.55) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL24669562 | 0.75 | CCNE1 (0.54) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL24668684 | 0.73 | CCNE1 (0.54) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL24669153 | 0.72 | CCNE1 (0.58) | CCNE1CDK2CCND1CDK6CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |