Pentachlorophenol

Pentachlorophenol

SCHEMBL246699

CC(=O)O.NCCNCCN.Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Pentachlorophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 5/20 0.46
CYP2C9 P11712 5/20 0.46
TSHR P16473 4/20 0.46
CYP2C19 P33261 2/20 0.46
HIF1A Q16665 3/20 0.41
PAOX Q6QHF9 3/20 0.39
LMNA P02545 3/20 0.39
ALDH1A1 P00352 3/20 0.39
CA12 O43570 3/20 0.39
CA6 P23280 3/20 0.39
CA7 P43166 3/20 0.39
CA9 Q16790 3/20 0.39
CA14 Q9ULX7 3/20 0.39
CA5B Q9Y2D0 3/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
HPGD P15428 2/20 0.39
HSD17B10 Q99714 2/20 0.39
MAPT P10636 1/20 0.39
RECQL P46063 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pentachlorophenol SCHEMBL8620218 0.98 CYP1A2 (0.44) CYP1A2CYP2C9TSHRCYP2C19HIF1A
Pentachlorophenol SCHEMBL2398810 0.98 CYP1A2 (0.44) CYP1A2CYP2C9TSHRCYP2C19HIF1A
Pentachlorophenol SCHEMBL963480 0.88 CA12 (0.50) CYP1A2CYP2C9TSHRCYP2C19HIF1A
Pentachlorophenol SCHEMBL20484423 0.86 CYP1A2 (0.48) CYP1A2CYP2C9TSHRCYP2C19HIF1A
Pentachlorophenol SCHEMBL1528129 0.86 CYP1A2 (0.48) CYP1A2CYP2C9TSHRCYP2C19HIF1A
Pentachlorophenol SCHEMBL5378694 0.86 CYP1A2 (0.48) CYP1A2CYP2C9TSHRCYP2C19HIF1A
Pentachlorophenol SCHEMBL1990677 0.83 CYP1A2 (0.40) CYP1A2CYP2C9TSHRCYP2C19HIF1A
Acetic Acid SCHEMBL863599 0.81 CA12 (0.59) CYP1A2CYP2C9TSHRCYP2C19PAOX
Acetic Acid SCHEMBL3657736 0.81 CA12 (0.59) CYP1A2CYP2C9TSHRCYP2C19PAOX
Acetic Acid SCHEMBL18288 0.81 CA12 (0.59) CYP1A2CYP2C9TSHRCYP2C19PAOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 197 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3083703-B1 PROCESS FOR EXTRACTION OF CALCIUM SENSITIVE PECTIN DUPONT NUTRITION BIOSCI APS (DK) 2022-08-10 EP claimed
EP-2788194-B1 HOT MELT CLEANING COMPOSITION, METHOD FOR PREPARING A HOT MELT CLEANING COMPOSITION AND USE THEREOF OCE TECH BV (NL) 2019-10-02 EP claimed
US-20180345216-A1 FLUID FOR CARRYING OUT POLLUTION CONTROL IN HEAT ENGINES, AND METHODS FOR PREPARING SAID FLUIDS BY PRODUCING A HOMOGENEOUS SOLUTION IFP Energies Nouvelles (FR) 2018-12-06 US claimed
EP-3083703-A1 PROCESS FOR EXTRACTION OF CALCIUM SENSITIVE PECTIN DuPont Nutrition Biosciences ApS (DK) 2016-10-26 EP claimed
WO-2015091629-A1 PROCESS FOR EXTRACTION OF CALCIUM SENSITIVE PECTIN DUPONT NUTRITION BIOSCIENCES APS (DK) 2015-06-25 WO claimed
US-20130231302-A1 ANTIMICROBIAL SOLUTIONS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2013-09-05 US claimed
WO-2012125894-A2 OXIDATION INHIBITORS FOR AMINE DEGRADATION BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-09-20 WO claimed
WO-2012034032-A2 ANTIMICROBIAL SOLUTIONS THE BOARD OF REGENTS OF UNBIVERSITY OF TEXAS SYSTEM (US) 2012-03-15 WO claimed
US-20110201692-A1 ANTIMICROBIAL FLUSH SOLUTIONS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2011-08-18 US claimed
US-20100055086-A1 Antimicrobial Flush Solutions RAAD ISSAM 2010-03-04 US claimed
EP-1644024-A2 ANTIMICROBIAL FLUSH SOLUTIONS Board of Regents, The University of Texas System (US) 2006-04-12 EP claimed
US-20050013836-A1 Antimicrobial flush solutions BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2005-01-20 US claimed
WO-2004108091-A2 ANTIMICROBIAL FLUSH SOLUTIONS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2004-12-16 WO claimed
US-6187768-B1 DRY LYOPHILIZED UNIT DOSE OF ANTIMICROBIAL AGENT AND SECOND AGENT OF ANTICOAGULANT, ANTITHROMBOTIC AGENT AND/OR CHELATING AGENT BECTON, DICKINSON AND COMPANY 2001-02-13 US claimed
WO-2000072906-A1 KIT FOR FLUSHING MEDICAL DEVICES AND METHOD OF PREPARING THE FLUSHING SOLUTION BECTON, DICKINSON AND COMPANY (US) 2000-12-07 WO claimed
US-5898077-A Process for preparation of an ester MATSUMOTO YUSHI-SEIYAKU CO., LTD. (JP) 1999-04-27 US claimed
US-5760265-A Process for preparation of an ester utilizing an esterifying catalyst MATSUMOTO YUSHI SEIYAKU CO., LTD. (JP) 1998-06-02 US claimed
US-5688516-A Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1997-11-18 US claimed
WO-1995025195-A1 TEXTILE BLEACHING PROCESS SOLVAY INTEROX LIMITED (GB) 1995-09-21 WO claimed
EP-0301477-A2 Silver halide color photosensitive material and method of processing thereof Fuji Photo Film Co., Ltd. (JP) 1989-02-01 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130231302-A1 ANTIMICROBIAL SOLUTIONS UGCG, GANAB, GANC CYP1A2 4051/4885CYP2C9 4291/4885TSHR 4296/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.