Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | ITK | Q08881 | 5/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | IL2 | P60568 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066213 | 1.00 | RET (0.38) | RETKDRITKCASP3SENP8 | |
| SCHEMBL30801213 | 0.97 | ITK (0.37) | RETKDRITKCASP3SENP8 | |
| SCHEMBL30066227 | 0.88 | ITK (0.31) | ITKIL2 | |
| SCHEMBL24670748 | 0.88 | ITK (0.31) | ITKIL2 | |
| SCHEMBL30066236 | 0.88 | ITK (0.31) | ITKIL2 | |
| SCHEMBL24671283 | 0.87 | RET (0.33) | RETKDRITKABL1 | |
| SCHEMBL24670121 | 0.87 | RET (0.33) | RETKDRITKABL1 | |
| SCHEMBL29990667 | 0.87 | RET (0.33) | RETKDRITKABL1 | |
| SCHEMBL24669865 | 0.87 | HDAC4 (0.34) | RETKDRCHEK2ABL1 | |
| SCHEMBL30863346 | 0.85 | ITK (0.42) | RETITKIL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |