Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.43 |
| ▸ | CCND1 | P24385 | 9/20 | 0.43 |
| ▸ | CCND2 | P30279 | 9/20 | 0.43 |
| ▸ | CCND3 | P30281 | 9/20 | 0.43 |
| ▸ | CDK2 | P24941 | 9/20 | 0.43 |
| ▸ | CDK1 | P06493 | 8/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.43 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670052 | 0.78 | CCNE1 (0.53) | CDK4CCND1CCND3CDK2CCNE1 | |
| SCHEMBL24669173 | 0.77 | CDK4 (0.38) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6809364 | 0.77 | CDK4 (0.71) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL24669150 | 0.76 | CDK4 (0.39) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL24669186 | 0.75 | CHRM1 (0.37) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL24668611 | 0.74 | CA1 (0.41) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL24670049 | 0.74 | CA1 (0.43) | CCND3CDK2CDK1FGFR1CCNE2 | |
| SCHEMBL6803070 | 0.74 | CDK4 (0.70) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL24670051 | 0.74 | HTT (0.50) | CDK2CDK1FGFR1CCNB1CCNA2 | |
| SCHEMBL6808164 | 0.73 | CDK4 (0.58) | CDK4CCND1CCND2CCND3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |