Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.33 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521541 | 0.82 | HTT (0.48) | HTTALDH1A1MAPTSMN1; SMN2SYK | |
| SCHEMBL23142016 | 0.80 | HTT (0.46) | HTTCDK2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL23142017 | 0.80 | HTT (0.46) | HTTCDK2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL22860104 | 0.79 | HTT (0.46) | HTTCDK2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL23142093 | 0.77 | HTT (0.45) | HTTALDH1A1MAPTSMN1; SMN2SYK | |
| SCHEMBL23142092 | 0.77 | HTT (0.45) | HTTALDH1A1MAPTSMN1; SMN2SYK | |
| SCHEMBL22860671 | 0.77 | HTT (0.46) | HTTCDK2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL23141915 | 0.76 | HTT (0.44) | HTTALDH1A1MAPTSMN1; SMN2SYK | |
| SCHEMBL23141916 | 0.76 | HTT (0.44) | HTTALDH1A1MAPTSMN1; SMN2SYK | |
| SCHEMBL1521589 | 0.74 | HTT (0.51) | HTTALDH1A1MAPTSMN1; SMN2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |