Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.53 |
| ▸ | GSK3B | P49841 | 9/20 | 0.53 |
| ▸ | CDK9 | P50750 | 7/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.53 |
| ▸ | CDK1 | P06493 | 5/20 | 0.53 |
| ▸ | CDK7 | P50613 | 4/20 | 0.53 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.53 |
| ▸ | GSK3A | P49840 | 2/20 | 0.53 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.53 |
| ▸ | CCNK | O75909 | 2/20 | 0.53 |
| ▸ | CCNH | P51946 | 2/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.53 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.53 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24667992 | 0.84 | GSK3B (0.48) | CDK2GSK3BCDK9CCNE1CDK5 | |
| SCHEMBL24670105 | 0.83 | GSK3B (0.47) | CDK2GSK3BCDK9CCNE1CDK5 | |
| SCHEMBL24669687 | 0.82 | GSK3B (0.45) | CDK2GSK3BCDK9CCNE1CDK5 | |
| SCHEMBL14346547 | 0.80 | CDK2 (0.59) | CDK2GSK3BCDK9CCNE1CDK5 | |
| SCHEMBL16198015 | 0.80 | CDK2 (0.75) | CDK2GSK3BCDK9CCNE1CDK5 | |
| SCHEMBL12953706 | 0.80 | CDK2 (0.75) | CDK2GSK3BCDK9CCNE1CDK5 | |
| SCHEMBL14389785 | 0.79 | CDK2 (0.59) | CDK2GSK3BCDK9CCNE1CDK5 | |
| SCHEMBL14364517 | 0.79 | CDK2 (0.59) | CDK2GSK3BCDK9CCNE1CDK5 | |
| SCHEMBL14346160 | 0.79 | CDK2 (0.59) | CDK2GSK3BCDK9CCNE1CDK5 | |
| SCHEMBL14364518 | 0.78 | CDK2 (0.57) | CDK2GSK3BCDK9CCNE1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |