Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND1 | P24385 | 15/20 | 0.88 |
| ▸ | CDK4 | P11802 | 14/20 | 0.88 |
| ▸ | CCND2 | P30279 | 14/20 | 0.88 |
| ▸ | CCND3 | P30281 | 14/20 | 0.88 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.62 |
| ▸ | CDK2 | P24941 | 2/20 | 0.62 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.62 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.62 |
| ▸ | CDK1 | P06493 | 1/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.62 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.62 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.62 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.62 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359995 | 0.94 | CCND1 (1.00) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL14932668 | 0.87 | CDK4 (0.72) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL3304050 | 0.82 | CCND1 (0.79) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL31053648 | 0.82 | CDK4 (0.76) | CCND1CDK4CCND2CCND3CCNE1 | |
| SCHEMBL3304038 | 0.81 | MAPK8 (0.71) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL3304031 | 0.81 | MAPK8 (0.71) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL7796726 | 0.81 | MAPK8 (0.71) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL189662 | 0.81 | CDK4 (1.00) | CCND1CDK4CCND2CCND3CCNE1 | |
| SCHEMBL23141627 | 0.80 | CDK4 (0.72) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL23141626 | 0.80 | CDK4 (0.72) | CCND1CDK4CCND2CCND3MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |