Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND1 | P24385 | 10/20 | 0.72 |
| ▸ | CDK4 | P11802 | 5/20 | 0.72 |
| ▸ | CCND2 | P30279 | 2/20 | 0.72 |
| ▸ | CCND3 | P30281 | 2/20 | 0.72 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.69 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.69 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.59 |
| ▸ | CDK2 | P24941 | 9/20 | 0.59 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.59 |
| ▸ | CDK9 | P50750 | 3/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3304431 | 1.00 | CCND1 (0.72) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL16802596 | 0.90 | MAPK8 (0.82) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL18160381 | 0.88 | MAPK8 (0.58) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL18148245 | 0.87 | MAPK8 (0.73) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL3305016 | 0.87 | MAPK8 (0.73) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL16802606 | 0.87 | MAPK8 (0.73) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL16799550 | 0.87 | MAPK8 (0.73) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL7794897 | 0.87 | MAPK8 (0.73) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL16802597 | 0.86 | MAPK8 (0.67) | CCND1CDK4CCND2CCND3MAPK8 | |
| SCHEMBL22787390 | 0.84 | MAPK8 (0.60) | CCND1CDK4CCND2CCND3MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |