Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 13/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 11/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.59 |
| ▸ | CDK4 | P11802 | 6/20 | 0.55 |
| ▸ | CCND1 | P24385 | 6/20 | 0.55 |
| ▸ | CCND2 | P30279 | 4/20 | 0.55 |
| ▸ | CCND3 | P30281 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670363 | 0.94 | MAPK8 (0.61) | MAPK8MAPK10MAPK9CDK4CCND1 | |
| SCHEMBL16802573 | 0.82 | MAPK8 (0.82) | MAPK8MAPK10MAPK9CDK4CCND1 | |
| SCHEMBL25004173 | 0.80 | CDK4 (0.67) | MAPK8MAPK10MAPK9CDK4CCND1 | |
| SCHEMBL24670370 | 0.79 | CDK4 (0.63) | MAPK8MAPK10MAPK9CDK4CCND1 | |
| SCHEMBL24669972 | 0.76 | CDK4 (0.69) | MAPK8MAPK10MAPK9CDK4CCND1 | |
| SCHEMBL24670368 | 0.74 | CDK2 (0.77) | MAPK8MAPK10MAPK9CDK4CCND1 | |
| SCHEMBL18148266 | 0.74 | MAPK8 (1.00) | MAPK8MAPK10MAPK9CDK4CCND1 | |
| SCHEMBL18148254 | 0.74 | MAPK8 (1.00) | MAPK8MAPK10MAPK9CDK4CCND1 | |
| SCHEMBL24670365 | 0.74 | CDK2 (0.77) | MAPK8MAPK10MAPK9CDK4CCND1 | |
| SCHEMBL16802772 | 0.74 | MAPK8 (1.00) | MAPK8MAPK10MAPK9CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |