Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 20/20 | 0.51 |
| ▸ | CDK2 | P24941 | 20/20 | 0.51 |
| ▸ | CCND1 | P24385 | 18/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 18/20 | 0.51 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CCND3 | P30281 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.47 |
| ▸ | RB1 | P06400 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24669658 | 0.86 | CCNE1 (0.68) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24670447 | 0.77 | CCNE1 (0.70) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22259331 | 0.77 | CDK2 (0.46) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669140 | 0.74 | CCNE1 (0.74) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669210 | 0.74 | CCNE1 (0.70) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669659 | 0.73 | CCNE1 (0.61) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669660 | 0.72 | CCNE1 (0.60) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669203 | 0.71 | CCNE1 (0.63) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL23340893 | 0.69 | CCNE1 (0.74) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24668696 | 0.69 | CCNE1 (0.65) | CCNE1CDK2CCND1CDK6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |