Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND1 | P24385 | 16/20 | 0.56 |
| ▸ | CDK4 | P11802 | 5/20 | 0.56 |
| ▸ | CCND2 | P30279 | 2/20 | 0.56 |
| ▸ | CCND3 | P30281 | 2/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.46 |
| ▸ | CDK2 | P24941 | 16/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 14/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.45 |
| ▸ | CDK9 | P50750 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670502 | 0.96 | CCND1 (0.49) | CCND1CDK4CCND2CCND3CCNE1 | |
| SCHEMBL24668813 | 0.92 | MAPK8 (0.49) | CCND1CDK4CCND2CCND3CCNE1 | |
| SCHEMBL24667904 | 0.90 | CCNE1 (0.54) | CCND1CDK4CCND3CCNE1CDK2 | |
| SCHEMBL24669765 | 0.89 | CCND1 (0.43) | CCND1CDK4CCND2CCND3CCNE1 | |
| SCHEMBL24669772 | 0.89 | CCND1 (0.47) | CCND1CDK4CCND2CCND3CCNE1 | |
| SCHEMBL24669767 | 0.89 | MAPK8 (0.45) | CCND1CDK4CCND2CCND3CCNE1 | |
| SCHEMBL24668739 | 0.88 | CCND1 (0.43) | CCND1CDK4CCND2CCND3CCNE1 | |
| SCHEMBL24669771 | 0.85 | CCND1 (0.41) | CCND1CDK4CCND2CCND3CCNE1 | |
| SCHEMBL24668729 | 0.84 | CCNE1 (0.56) | CCND1CDK4CCND3CCNE1CDK2 | |
| SCHEMBL24670510 | 0.84 | CDK4 (0.42) | CCND1CDK4CCND2CCND3CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |