Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 15/20 | 0.39 |
| ▸ | LCAT | P04180 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066348 | 1.00 | CRBN (0.39) | CRBNDDB1LCATSYKPDE10A | |
| SCHEMBL24880727 | 0.89 | FFAR4 (0.39) | CRBNDDB1 | |
| SCHEMBL24880883 | 0.88 | CRBN (0.36) | CRBNDDB1LCAT | |
| SCHEMBL24881066 | 0.87 | CRBN (0.43) | CRBNDDB1 | |
| SCHEMBL31583448 | 0.87 | CRBN (0.43) | CRBNDDB1 | |
| Hydrochloric Acid SCHEMBL31583577 | 0.86 | CRBN (0.43) | CRBNDDB1 | |
| SCHEMBL24881292 | 0.86 | CRBN (0.44) | CRBNDDB1LCAT | |
| SCHEMBL24880878 | 0.85 | POLB (0.35) | CRBNDDB1 | |
| SCHEMBL24671454 | 0.84 | CRBN (0.40) | CRBNDDB1LCAT | |
| SCHEMBL30066549 | 0.84 | CRBN (0.40) | CRBNDDB1LCAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693502-A | Compounds for inhibiting or degrading ITK, compositions comprising the same, methods of making the same, and methods of using the same | 纽力克斯治疗公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |