Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066382 | 1.00 | CRBN (0.55) | CRBNDDB1IKZF3BRD4PDE3B | |
| SCHEMBL24671237 | 0.91 | CRBN (0.51) | CRBNDDB1IKZF3BRD4PARP1 | |
| SCHEMBL24671242 | 0.90 | CRBN (0.57) | CRBNDDB1IKZF3BRD4PARP1 | |
| SCHEMBL24421608 | 0.89 | CRBN (0.56) | CRBNDDB1IKZF3BRD4PARP1 | |
| SCHEMBL24671244 | 0.89 | CRBN (0.58) | CRBNDDB1IKZF3BRD4PARP1 | |
| SCHEMBL30801203 | 0.89 | CRBN (0.58) | CRBNDDB1IKZF3BRD4PARP1 | |
| SCHEMBL27238850 | 0.88 | CRBN (0.55) | CRBNDDB1IKZF3BRD4PARP1 | |
| SCHEMBL27238855 | 0.88 | CRBN (0.55) | CRBNDDB1IKZF3BRD4PARP1 | |
| SCHEMBL24421607 | 0.88 | CRBN (0.55) | CRBNDDB1IKZF3BRD4PARP1 | |
| SCHEMBL31756551 | 0.88 | CRBN (0.57) | CRBNDDB1IKZF3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |