Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 9/20 | 0.42 |
| ▸ | IL2 | P60568 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 5/20 | 0.34 |
| ▸ | PIP5K1C | O60331 | 4/20 | 0.33 |
| ▸ | ATR | Q13535 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24671305 | 1.00 | ITK (0.42) | ITKIL2PARP1PIP5K1CATR | |
| SCHEMBL31055473 | 1.00 | ITK (0.42) | ITKIL2PARP1PIP5K1CATR | |
| SCHEMBL24670141 | 0.93 | ITK (0.41) | ITKIL2PARP1PIP5K1C | |
| SCHEMBL31055554 | 0.87 | ITK (0.42) | ITKIL2PIP5K1C | |
| SCHEMBL29990936 | 0.86 | ITK (0.44) | ITKIL2PIP5K1C | |
| SCHEMBL30066409 | 0.86 | KDR (0.45) | ITKIL2PARP1PIP5K1C | |
| SCHEMBL24671834 | 0.86 | ITK (0.44) | ITKIL2PIP5K1C | |
| SCHEMBL24671193 | 0.86 | KDR (0.45) | ITKIL2PARP1PIP5K1C | |
| SCHEMBL24671679 | 0.86 | ITK (0.44) | ITKIL2PIP5K1C | |
| SCHEMBL24671255 | 0.84 | ITK (0.47) | ITKPARP1PIP5K1CATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |