Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.64 |
| ▸ | IKZF3 | Q9UKT9 | 8/20 | 0.62 |
| ▸ | TNF | P01375 | 6/20 | 0.62 |
| ▸ | IL1B | P01584 | 4/20 | 0.62 |
| ▸ | IKZF1 | Q13422 | 3/20 | 0.62 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.62 |
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.50 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25568961 | 0.99 | CRBN (0.62) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL31628528 | 0.99 | CRBN (0.62) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL26317801 | 0.93 | CRBN (0.69) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL3549412 | 0.92 | CRBN (0.67) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL19453156 | 0.89 | CRBN (0.65) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL31381350 | 0.89 | CRBN (0.64) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL29878325 | 0.89 | CRBN (0.65) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL27290384 | 0.89 | CRBN (0.59) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL2030317 | 0.89 | CRBN (0.72) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL2032185 | 0.89 | CRBN (0.72) | CRBNIKZF3TNFIL1BIKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |