Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2471950 | 0.91 | EGLN1 (0.46) | EGLN1EGLN3EGLN2 | |
| SCHEMBL2470691 | 0.87 | EGLN1 (0.47) | EGLN1EGLN3EGLN2 | |
| SCHEMBL2472669 | 0.82 | EGLN1 (0.43) | EGLN1EGLN3 | |
| SCHEMBL2469234 | 0.81 | EGLN2 (0.45) | EGLN1EGLN3EGLN2 | |
| SCHEMBL2518895 | 0.77 | EGLN1 (0.37) | EGLN1EGLN3EGLN2TACR1 | |
| SCHEMBL2471244 | 0.76 | EGLN3 (0.52) | EGLN1EGLN3 | |
| SCHEMBL2473839 | 0.76 | EGLN1 (0.43) | EGLN1EGLN3EGLN2 | |
| SCHEMBL2470944 | 0.74 | EGLN1 (0.53) | EGLN1EGLN3 | |
| SCHEMBL2473879 | 0.73 | HPGD (0.44) | EGLN1EGLN3 | |
| SCHEMBL2470821 | 0.72 | EGLN1 (0.45) | EGLN1EGLN3EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370422-A1 | THIOCHROMENE DERIVATIVES AS HIP HYDROXYLASE INHIBITORS | Fibrogen, Inc. (US) | 2011-10-05 | — | — | EP | claimed |
| WO-2010056767-A1 | THIOCHROMENE DERIVATIVES AS HIP HYDROXYLASE INHIBITORS | FIBROGEN, INC. (US) | 2010-05-20 | — | — | WO | claimed |