Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 14/20 | 1.00 |
| ▸ | HCRTR2 | O43614 | 13/20 | 1.00 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196582 | 1.00 | HCRTR1 (1.00) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL196581 | 1.00 | HCRTR1 (1.00) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5207076 | 0.96 | HCRTR1 (0.92) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5210423 | 0.89 | HCRTR1 (0.81) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5207183 | 0.89 | HCRTR1 (0.79) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5207208 | 0.88 | HCRTR1 (0.79) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5207307 | 0.87 | HCRTR1 (0.78) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL198063 | 0.87 | HCRTR1 (1.00) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL30593432 | 0.87 | HCRTR1 (1.00) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL198064 | 0.87 | HCRTR1 (1.00) | HCRTR1HCRTR2MTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402322-A1 | 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist | Actelion Pharmaceuticals Ltd. (CH) | 2012-01-04 | — | — | EP | disclosed |