Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20873854 | 0.91 | HPGD (0.51) | NR1H2CNR1HPGDKDM4EPKM | |
| SCHEMBL1100404 | 0.90 | CNR1 (0.51) | NR1H2CNR1HPGDKDM4EPKM | |
| SCHEMBL20873836 | 0.90 | CNR1 (0.51) | NR1H2CNR1HPGDKDM4EPKM | |
| SCHEMBL5573169 | 0.90 | HPGD (0.53) | NR1H2CNR1HPGDKDM4EPKM | |
| SCHEMBL24745371 | 0.89 | CNR1 (0.45) | NR1H2CNR1HPGDKDM4EPKM | |
| SCHEMBL27308696 | 0.89 | CACNA2D1 (0.47) | NR1H2CNR1HPGDKDM4EPKM | |
| SCHEMBL20046379 | 0.89 | CNR1 (0.44) | NR1H2CNR1HPGDKDM4EPKM | |
| SCHEMBL29928185 | 0.87 | NR1H2 (0.56) | NR1H2CNR1HPGDKDM4EPKM | |
| SCHEMBL25133786 | 0.87 | NR1H2 (0.56) | NR1H2CNR1HPGDKDM4EPKM | |
| SCHEMBL27432720 | 0.87 | CACNA2D1 (0.48) | NR1H2CNR1HPGDKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |