Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 4/20 | 0.38 |
| ▸ | PARP1 | P09874 | 8/20 | 0.38 |
| ▸ | IL2 | P60568 | 1/20 | 0.37 |
| ▸ | PIP5K1C | O60331 | 4/20 | 0.33 |
| ▸ | VCP | P55072 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24671700 | 0.90 | ITK (0.39) | ITKPARP1IL2PIP5K1CCHEK1 | |
| SCHEMBL24670156 | 0.90 | ITK (0.39) | ITKPARP1IL2PIP5K1CVCP | |
| SCHEMBL31055474 | 0.89 | ITK (0.35) | ITKPARP1IL2 | |
| SCHEMBL31055490 | 0.89 | ITK (0.35) | ITKPARP1IL2 | |
| SCHEMBL24671472 | 0.89 | ITK (0.35) | ITKPARP1IL2 | |
| SCHEMBL24671450 | 0.89 | ITK (0.35) | ITKPARP1IL2 | |
| SCHEMBL24671473 | 0.89 | ITK (0.35) | ITKPARP1IL2 | |
| SCHEMBL24671655 | 0.88 | ITK (0.34) | ITKPARP1IL2 | |
| SCHEMBL24671485 | 0.86 | ITK (0.34) | ITKPARP1IL2 | |
| SCHEMBL24671189 | 0.86 | ITK (0.34) | ITKPARP1IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |