Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 4/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | BCL2 | P10415 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.42 |
| ▸ | PDE6D | O43924 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | IRAK3 | Q9Y616 | 3/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24671771 | 0.99 | STAT3 (0.48) | STAT3CRBNDDB1DYRK2CA2 | |
| SCHEMBL24979657 | 0.99 | STAT3 (0.48) | STAT3CRBNDDB1DYRK2CA2 | |
| SCHEMBL23946161 | 0.92 | STAT3 (0.48) | STAT3CRBNDDB1DYRK2CA2 | |
| SCHEMBL23915711 | 0.91 | CRBN (0.47) | STAT3CRBNDDB1CA2HDAC1 | |
| SCHEMBL22511915 | 0.89 | STAT3 (0.47) | STAT3CRBNDDB1DYRK2CA2 | |
| SCHEMBL20260253 | 0.88 | CRBN (0.51) | STAT3CRBNDDB1DYRK2CA2 | |
| SCHEMBL22959685 | 0.87 | STAT3 (0.44) | STAT3CRBNDDB1DYRK2CA2 | |
| SCHEMBL26366310 | 0.86 | STAT3 (0.44) | STAT3CRBNDDB1DYRK2CA2 | |
| SCHEMBL23945868 | 0.86 | CRBN (0.48) | STAT3CRBNDDB1DYRK2CA2 | |
| SCHEMBL23915176 | 0.85 | CRBN (0.46) | STAT3CRBNDDB1CA2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |