SCHEMBL24671930 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	SOS1	Q07889	20/20	0.63

▸	KRAS	P01116	2/20	0.61

▸	CYP3A4	P08684	2/20	0.61

▸	CYP2C8	P10632	2/20	0.61

▸	CYP2D6	P10635	2/20	0.61

▸	CYP2C9	P11712	2/20	0.61

▸	CYP2C19	P33261	1/20	0.61

▸	KCNH2	Q12809	1/20	0.61

▸	CRBN	Q96SW2	1/20	0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL29849386	0.89	SOS1 (0.75)	SOS1KRASCYP3A4CYP2C8CYP2D6
SCHEMBL24671932	0.89	SOS1 (0.75)	SOS1KRASCYP3A4CYP2C8CYP2D6
SCHEMBL29849057	0.86	SOS1 (0.66)	SOS1KRASCYP3A4CYP2C8CYP2D6
SCHEMBL24671888	0.86	SOS1 (0.66)	SOS1KRASCYP3A4CYP2C8CYP2D6
SCHEMBL29301811	0.85	SOS1 (0.79)	SOS1KRASCYP3A4CYP2C8CYP2D6
SCHEMBL29297242	0.79	SOS1 (0.71)	SOS1KRASCYP3A4CYP2C8CYP2D6
SCHEMBL24671924	0.78	SOS1 (0.73)	SOS1KRASCYP3A4CYP2C8CYP2D6
SCHEMBL29058991	0.78	SOS1 (0.69)	SOS1KRASCYP3A4CYP2C8CYP2D6
SCHEMBL29058990	0.78	SOS1 (0.69)	SOS1KRASCYP3A4CYP2C8CYP2D6
SCHEMBL29849063	0.78	SOS1 (0.73)	SOS1KRASCYP3A4CYP2C8CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022170802-A1	PYRIMIDO-PYRIDONE DERIVATIVE AS SOS1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF	苏州阿尔脉生物科技有限公司	2022-08-18	—	—	WO	disclosed