SCHEMBL24672310

SCHEMBL24672310

C[C@H](Nc1cc(Cl)nc2c1cnn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1N)c1ccccc1F

nearest known ligand 0.65

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NT5E P21589 12/20 0.65
ADORA2A P29274 2/20 0.43
ADORA2B P29275 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30008475 0.93 NT5E (0.73) NT5EADORA2AADORA2B
SCHEMBL27206559 0.93 NT5E (0.73) NT5EADORA2AADORA2B
SCHEMBL22104978 0.93 NT5E (0.73) NT5EADORA2AADORA2B
SCHEMBL24672309 0.93 NT5E (0.73) NT5EADORA2AADORA2B
SCHEMBL27206674 0.87 NT5E (0.62) NT5EADORA2AADORA2B
SCHEMBL27206875 0.87 NT5E (0.62) NT5EADORA2AADORA2B
SCHEMBL27195198 0.87 NT5E (0.62) NT5EADORA2AADORA2B
SCHEMBL27195236 0.87 NT5E (0.62) NT5EADORA2AADORA2B
SCHEMBL24118835 0.86 NT5E (0.62) NT5EADORA2AADORA2B
SCHEMBL27195140 0.85 NT5E (0.90) NT5E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022237747-A1 SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF 四川海思科制药有限公司 2022-11-17 WO disclosed