Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.62 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1820693 | 0.86 | PIK3CA (0.75) | PIK3CAPIK3CBPIK3CGMTORPIK3CD | |
| SCHEMBL1821931 | 0.85 | PIK3CA (0.77) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL2466229 | 0.84 | PIK3CA (0.76) | PIK3CAPIK3CBPIK3CGMTORPIK3CD | |
| SCHEMBL2467294 | 0.83 | PIK3CA (0.78) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL2468036 | 0.83 | PIK3CA (0.70) | PIK3CAPIK3CBPIK3CGMTORPIK3CD | |
| SCHEMBL1822162 | 0.82 | PIK3CA (0.73) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1819510 | 0.81 | PIK3CA (0.89) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1823444 | 0.81 | PIK3CA (0.68) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1827536 | 0.81 | PIK3CA (0.88) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1826851 | 0.81 | PIK3CA (1.00) | PIK3CAPIK3CBPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575940-B1 | 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | NOVARTIS AG (CH) | 2011-10-05 | — | — | EP | claimed |