Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460188 | 0.87 | IGF1R (0.43) | IGF1RTNK2 | |
| SCHEMBL2459605 | 0.86 | IGF1R (0.50) | IGF1RTNK2 | |
| SCHEMBL2461512 | 0.86 | IGF1R (0.40) | IGF1RPRMT5TNK2 | |
| SCHEMBL2460257 | 0.85 | IGF1R (0.40) | IGF1RPLATTNK2 | |
| SCHEMBL2459995 | 0.85 | IGF1R (0.40) | IGF1RTNK2 | |
| SCHEMBL2458195 | 0.85 | IGF1R (0.47) | IGF1RPLATPRMT5TNK2 | |
| SCHEMBL2457535 | 0.83 | IGF1R (0.38) | IGF1RTNK2 | |
| SCHEMBL2460547 | 0.82 | IGF1R (0.48) | IGF1RTNK2 | |
| SCHEMBL2459690 | 0.82 | IGF1R (0.37) | IGF1RPLATTNK2 | |
| SCHEMBL2467426 | 0.82 | TNK2 (0.40) | IGF1RPRMT5TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675860-B1 | IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS | OSI PHARM INC (US) | 2011-09-21 | — | — | EP | claimed |