Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21443156 | 0.90 | ALK (0.61) | ALKKDRKIT | |
| SCHEMBL20004239 | 0.89 | ALK (0.60) | ALKKDRKIT | |
| SCHEMBL20366556 | 0.88 | ALK (0.73) | ALKKDR | |
| SCHEMBL20004124 | 0.87 | ALK (0.56) | ALKKDRKIT | |
| SCHEMBL20366581 | 0.87 | ALK (0.54) | ALKKDRKIT | |
| SCHEMBL897747 | 0.85 | ALK (0.79) | ALKKDRKIT | |
| SCHEMBL24675692 | 0.85 | ALK (0.59) | ALKKDR | |
| SCHEMBL20004738 | 0.84 | ALK (0.75) | ALKKDRKIT | |
| SCHEMBL25447243 | 0.82 | ALK (0.69) | ALKKDRKIT | |
| SCHEMBL21443254 | 0.81 | ALK (0.73) | ALKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230142119-A1 | TETRACYCLIC COMPOUND | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2023-05-11 | — | — | US | disclosed |
| US-20220306578-A1 | TETRACYCLIC COMPOUND | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2022-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230142119-A1 | TETRACYCLIC COMPOUND | ALK, TTR, ACVR1 | ALK 1/4885KDR 167/4885KIT 378/4885 |
| US-20220306578-A1 | TETRACYCLIC COMPOUND | ALK, TTR, ACVR1 | ALK 1/4885KDR 167/4885KIT 378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.