Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 6/20 | 0.36 |
| ▸ | HRH1 | P35367 | 6/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29822868 | 1.00 | PDE3B (0.38) | PDE3BPDE3AP2RY12PPARGPPARA | |
| SCHEMBL29823042 | 1.00 | PDE3B (0.38) | PDE3BPDE3AP2RY12PPARGPPARA | |
| SCHEMBL25824597 | 0.83 | ROCK1 (0.40) | PPARGPPARA | |
| SCHEMBL25824210 | 0.83 | ROCK1 (0.40) | PPARGPPARA | |
| Hydrochloric Acid SCHEMBL29822777 | 0.81 | PDE3B (0.42) | PDE3BPDE3AP2RY12PPARGPPARA | |
| SCHEMBL29822802 | 0.81 | CA12 (0.41) | PDE3BPDE3AP2RY12CA12CA1 | |
| SCHEMBL25824077 | 0.74 | PDE3B (0.41) | PDE3BPDE3AP2RY12PPARGPPARA | |
| SCHEMBL28333021 | 0.74 | PDE2A (0.45) | PDE2A | |
| SCHEMBL25829471 | 0.74 | ROCK1 (0.41) | — | |
| SCHEMBL30490950 | 0.74 | ROCK1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |