Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 10/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 4/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | ACACA | Q13085 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24675847 | 1.00 | ACACB (0.48) | ACACBITGB3ITGA2BCA12CA1 | |
| SCHEMBL24674884 | 1.00 | ACACB (0.48) | ACACBITGB3ITGA2BCA12CA1 | |
| SCHEMBL24675528 | 0.92 | ACACB (0.53) | ACACBITGB3ITGA2BCTSKACACA | |
| SCHEMBL24675529 | 0.92 | ACACB (0.53) | ACACBITGB3ITGA2BCTSKACACA | |
| SCHEMBL29023015 | 0.88 | ACACB (0.49) | ACACBITGB3ITGA2BCA12CA1 | |
| SCHEMBL13920480 | 0.86 | ACACB (0.51) | ACACBITGB3ITGA2BCTSKACACA | |
| SCHEMBL24675230 | 0.85 | ROCK1 (0.45) | ACACBCTSKACACAALDH1A1 | |
| SCHEMBL24675892 | 0.85 | ACACB (0.49) | ACACBITGB3ITGA2BCA12CA1 | |
| SCHEMBL24675894 | 0.85 | GAA (0.52) | ACACBITGB3ITGA2BCA12CA1 | |
| SCHEMBL24675658 | 0.85 | ACACB (0.49) | ACACBITGB3ITGA2BCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |