SCHEMBL2467673

SCHEMBL2467673

CC(=O)Nc1nc2c(ncn2COC(COC(C)=O)COC(C)=O)c(=O)[nH]1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.71
KMT2A Q03164 3/20 0.71
TSHR P16473 2/20 0.71
PDE3A Q14432 1/20 0.52
BLM P54132 2/20 0.51
ALDH1A1 P00352 1/20 0.51
LMNA P02545 1/20 0.51
CYP3A4 P08684 1/20 0.51
NFKB1 P19838 1/20 0.51
VCP P55072 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
HIF1A Q16665 1/20 0.51
TAS1R3 Q7RTX0 1/20 0.44
TAS1R1 Q7RTX1 1/20 0.44
HBB P68871 2/20 0.41
MAPK1 P28482 1/20 0.41
USP2 O75604 1/20 0.40
PNP P00491 1/20 0.40
EDNRA P25101 1/20 0.40
HTR2A P28223 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9022143 0.91 KMT2A (0.62) MEN1KMT2ATSHRPDE3ABLM
SCHEMBL14421495 0.91 MEN1 (0.70) MEN1KMT2ATSHRPDE3ABLM
SCHEMBL10364407 0.90 MEN1 (0.61) MEN1KMT2ATSHRPDE3ABLM
SCHEMBL2576527 0.89 MEN1 (0.66) MEN1KMT2ATSHRPDE3ABLM
SCHEMBL14963622 0.89 KMT2A (0.66) MEN1KMT2ATSHRPDE3ABLM
SCHEMBL10481450 0.88 MEN1 (0.72) MEN1KMT2ATSHRPDE3ABLM
SCHEMBL14421454 0.86 MEN1 (0.69) MEN1KMT2ATSHRPDE3ABLM
SCHEMBL14963621 0.86 MEN1 (0.63) MEN1KMT2ATSHRPDE3ABLM
SCHEMBL8446145 0.84 MEN1 (0.67) MEN1KMT2ATSHRPDE3ABLM
SCHEMBL9583727 0.84 BLM (0.72) MEN1KMT2ATSHRPDE3ABLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1565470-A2 PROCESS FOR THE PREPARATION OF GANCICLOVIR Ranbaxy Laboratories Limited (IN) 2005-08-24 EP claimed
WO-2004039808-A2 PROCESS FOR THE PREPARATION OF GANCICLOVIR RANBAXY LABORATORIES LIMITED (US) 2004-05-13 WO claimed
CN-115724845-B Triacetyl ganciclovir preparation method of pyrrosir 湖北省宏源药业科技股份有限公司 2025-02-11 CN disclosed
CN-113929580-B Method for recovering side chains in ganciclovir condensate mother liquor 湖北省宏源药业科技股份有限公司 2024-10-18 CN disclosed
CN-114478531-B Method for recycling ganciclovir condensate synthetic mother liquor 湖北省宏源药业科技股份有限公司 2024-09-10 CN disclosed
CN-113149988-B Preparation method and application of ganciclovir 海南锦瑞制药有限公司 2023-04-28 CN disclosed
CN-112608313-B Treatment method of mother liquor precipitate in production of triacetyl ganciclovir 河北合佳医药科技集团股份有限公司 2023-03-10 CN disclosed
CN-115724845-A Preparation method of high-purity triacetylganciclovir 湖北省宏源药业科技股份有限公司 2023-03-03 CN disclosed
CN-114478531-A Method for recycling ganciclovir condensation compound synthesis mother liquor 湖北省宏源药业科技股份有限公司 2022-05-13 CN disclosed
CN-113149988-A Ganciclovir preparation method and application 海南锦瑞制药有限公司 2021-07-23 CN disclosed
CN-108467396-B Ganciclovir preparation method 安徽海康药业有限责任公司 2021-07-20 CN disclosed
WO-2003033498-A2 A PROCESS FOR THE TREATMENT OF GANCICLOVIR INTERMEDIATE N2-ACETYL-9-(1, 3-DIACETOXY-2-PROPOXYMETHYL) GUANINE RANBAXY LABORATORIES LIMITED (IN) 2003-04-24 WO disclosed
EP-0532878-B1 Process for producing acyclic nucleosides AJINOMOTO KK (JP) 1999-06-30 EP disclosed
US-5648489-A PREPARING 9-((1,3-DIHYDROXY-2-PROPOXY)METHYL)GUANINE FROM A PROTECTED GUANINE AND 2-ACETOXYMETHOXY-1,3-DIACETOXYPROPANE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION (US) 1997-07-15 US disclosed
US-5583225-A REACTING N2, N9-DIPROTECTED GUANINE WITH DIACETOXYPROPANE IN THE PRESENCE OF A MIXTURE OF AN ACID AND ACETIC ANHYDRIDE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 1996-12-10 US disclosed
EP-0532878-A2 Process for producing acyclic nucleosides Ajinomoto Co., Inc. (JP) 1993-03-24 EP disclosed
US-4816447-A HERPES VIRUS MERCK & CO., INC. (US) 1989-03-28 US disclosed
EP-0074306-B1 ANTI-VIRAL GUANINE DERIVATIVES MERCK & CO. INC. (US) 1988-06-01 EP disclosed
EP-0165164-A1 Anti-viral compounds, their preparation and anti-viral compositions MERCK & CO. INC. (US) 1985-12-18 EP disclosed
EP-0074306-A2 Anti-viral guanine derivatives MERCK & CO. INC. (US) 1983-03-16 EP disclosed