Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 11/20 | 0.46 |
| ▸ | GRM5 | P41594 | 10/20 | 0.46 |
| ▸ | CDK9 | P50750 | 3/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3435563 | 0.88 | GRM1 (0.47) | PDK4GRM1GRM5CDK9NAMPT | |
| SCHEMBL3435987 | 0.88 | PDK4 (0.48) | PDK4GRM1GRM5CDK9NAMPT | |
| SCHEMBL24678334 | 0.87 | GRM1 (0.41) | PDK4GRM1GRM5CDK9NAMPT | |
| SCHEMBL31639892 | 0.84 | PDK4 (0.49) | PDK4GRM1GRM5CDK9NAMPT | |
| SCHEMBL2079005 | 0.83 | PDK4 (0.53) | PDK4GRM1GRM5CDK9NAMPT | |
| SCHEMBL31462770 | 0.82 | PDK4 (0.48) | PDK4GRM1GRM5CDK9NAMPT | |
| SCHEMBL18589100 | 0.82 | PDK4 (0.48) | PDK4GRM1GRM5CDK9NAMPT | |
| SCHEMBL3817588 | 0.82 | PDK4 (0.49) | PDK4GRM1GRM5CDK9NAMPT | |
| SCHEMBL29976423 | 0.81 | NAMPT (0.50) | PDK4GRM1GRM5NAMPTALDH1A1 | |
| SCHEMBL27168139 | 0.81 | NAMPT (0.50) | PDK4GRM1GRM5NAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4083038-A1 | PYRIDAZINYL THIAZOLECARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |