Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.48 |
| ▸ | JAK2 | O60674 | 11/20 | 0.48 |
| ▸ | JAK3 | P52333 | 10/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30084225 | 1.00 | JAK1 (0.48) | JAK1JAK2JAK3TYK2HPGDS | |
| SCHEMBL24678139 | 0.88 | JAK1 (0.50) | JAK1JAK2JAK3TYK2HPGDS | |
| SCHEMBL30084223 | 0.88 | JAK1 (0.50) | JAK1JAK2JAK3TYK2HPGDS | |
| SCHEMBL30084191 | 0.87 | JAK1 (0.48) | JAK1JAK2JAK3HPGDS | |
| SCHEMBL24678718 | 0.87 | JAK1 (0.48) | JAK1JAK2JAK3HPGDS | |
| SCHEMBL24678153 | 0.85 | JAK1 (0.49) | JAK1JAK2JAK3TYK2HPGDS | |
| SCHEMBL30084164 | 0.85 | JAK1 (0.49) | JAK1JAK2JAK3TYK2HPGDS | |
| SCHEMBL30084185 | 0.85 | JAK2 (0.48) | JAK1JAK2JAK3TYK2HPGDS | |
| SCHEMBL24678708 | 0.85 | JAK2 (0.48) | JAK1JAK2JAK3TYK2HPGDS | |
| SCHEMBL24678437 | 0.84 | JAK1 (0.47) | JAK1JAK2JAK3HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022247676-A1 | COMPOUND WITH DIPYRROLOPYRIDINE STRUCTURE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 南京康屹生物医药中心(有限合伙) | 2022-12-01 | — | — | WO | disclosed |
| CN-115385911-A | Compound with dipyrrolopyridine structure, preparation method and medical application | 南京康屹生物医药中心(有限合伙) | 2022-11-25 | — | — | CN | disclosed |
| CN-113292561-A | Compound with dipyrrolopyridine structure, preparation method and medical application | 中国药科大学 | 2021-08-24 | — | — | CN | disclosed |